闫福華
電話:025-83620107郵箱:yanfh@nju.edu.cn 地址:研究方向:

組織工程與牙周再生治療;牙周病與全身系統性疾病的關系;牙周病的種植修複治療等

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闫福華,主任醫師、教授、博士研究生導師、伟德官网手机版附屬口腔醫院副院長。1985年畢業于遵義伟德官网手机版口腔醫學系,獲醫學學士學位;1993年畢業于北京醫科大學口腔伟德官网手机版(現北京大學),獲醫學博士學位,1998年國家公派訪問學者赴澳大利亞昆士蘭大學牙學院進行組織工程與牙周再生治療的研究。曾任福建醫科大學口腔伟德官网手机版及福建醫科大學附屬口腔醫院院長、福建醫科大學研究生教育學院院長、福建省口腔醫學會首任及第二屆會長、江蘇省口腔醫學會牙周病學專業委員會首任主任委員、武漢大學兼職教授、博士生導師。現任伟德官网手机版附屬口腔醫院副院長、博士研究生導師,享受國務院政府特殊津貼,中華口腔醫學會牙周病學專業委員會主任委員、江蘇省口腔醫學會副會長, “十三五規劃教材《牙周病學》副主編江蘇省雙創計劃人才,江蘇省特聘醫學專家,江蘇省六大人才高峰高層次人才等榮譽。主要研究領域為組織工程與牙周再生治療、牙周病與全身系統性疾病的關系、牙周病的種植修複治療等。先後主持省部級及以上科研項目18項(其中國家自然科學基金項目7項),發表論文300餘篇(其中International Journal of Oral Science, Journal ofDentalResearch, Journal of Clinical Periodontology, Journal of PeriodontologyJournal of Periodontal ResearchAdvanced Healthcare MaterialsBioactive materialsBiomaterials, TheranosticsAppliedMaterials Today等學術刊物 80餘篇)。主編、主譯學術專著26部。獲教育部科技進步獎二等獎1項(1/15),江蘇省醫學新技術引進一等獎1項(1/3)。福建省科學技術進步獎二等獎1項(1/5),福建省教學成果獎二等獎1項(2/6)。已培養畢業博士28人、碩士55人。現正指導博士後4人、在讀博士研究生6人、碩士研究生6人。


1.中華口腔醫學會牙周病學專業委員會主任委員

2.中華口腔醫學會理事

3.江蘇省口腔醫學會副會長

    4.中華口腔醫學雜志編委

5. International Journal of Oral Science編委

    6. Frontiers in Dental Medicine編委


1.Bao J, Li L, Zhang Y, Wang M,   Chen F, Ge S, Chen B*, Yan F*. Periodontitis may induce gut   microbiota dysbiosis via salivary microbiota[J]. Int J Oral Sci.   2022,14(1):32. (IF:24.897)

2.Lu J, Zhang S, Huang Y, Qian J, Tan B, Qian X, Zhuang J, Zou X, Li Y*, Yan F*. Periodontitis-related salivary microbiota aggravates Alzheimer's disease via gut-brain axis crosstalk[J]. Gut Microbes. 2022,14(1):2126272. (IF:9.434)

3.Qian J, Lu J, Huang Y, Wang M,   Chen B, Bao J, Wang L, Cui D, Luo B, Yan F*. Periodontitis salivary   microbiota worsens colitis[J]. J Dent Res. 2021,2021;220345211049781.   (IF:8.924)

4.Li L, Wang M, Bao J, Wang N,   Huang Y, He S, Chen B*, Yan F*.   Periodontitis may impair the homeostasis of systemic bone through regulation   of gut microbiota in ApoE-/- mice[J]. J Clin Periodontol. 2022 Jul 24. doi: 10.1111/jcpe.13708.   (IF:7.478)

5.Liao Y, Zhang M, Lin X*, Yan   F*. Diaryl urea derivative molecule inhibits cariogenic Streptococcus   mutans by affecting exopolysaccharide synthesis, stress response and nitrogen   metabolism[J]. Front Cell Infect Microbiol. 2022,12:904488. (IF:6.073)

6.Qiao D, Chen R, Li L, Zhu F,   Zhang Y*, Yan F*. Accelerated alveolar bone loss in a mouse model of   inflammatory bowel disease and its relationship with intestinal   inflammation[J]. J Periodontol. 2022,1-12. (IF:6.993)

7.Wang N, Zheng L, Qian J, Wang M, Li L, Huang Y, Zhang Q, Li Y*, Yan F*. Salivary microbiota of periodontitis aggravates bone loss in ovariectomized rats. Front Cell Infect Microbiol. 2022,12:983608. (IF:6.073)

5.Zhang M, Liao Y, Tong X*, Yan   F*. Novel urea derivative-loaded PLGA nanoparticles to inhibit   caries-associated Streptococcus mutans[J]. RSC Adv. 2022,12:4072-4080.   (IF:3.361)

6.Liao Y, Zhou C, Zhang Q, Wang X, Yan   F*, Xing X*. Prevalence of early childhood caries in three regions   of China: a cross-sectional study[J]. Int J Paediatr Dent. 2022,00:1-12.   (IF:3.455)

8.Cui D, Kong N, Ding L, Guo Y*,   Yang W*, Yan F*. Ultrathin 2D Titanium Carbide MXene (Ti3C2Tx)   nanoflakes activate WNT/HIF-1alpha-mediated metabolism reprogramming for   periodontal regeneration[J]. Adv Healthc Mater. 2021,2101215. (IF:9.933)

9.Zhang S, Zhou H, Kong N, Wang Z,   Fu H, Zhang Y, Xiao Y*, Yang W*, Yan F*. L-cysteine-modified chiral   gold nanoparticles promote periodontal tissue regeneration[J]. Bioact Mater.   2021,6:3288-3299. (IF:14.593)

10.Li L, Bao J, Chang Y, Wang M,   Chen B*, Yan F*. Gut microbiota may mediate the influence of   periodontitis on prediabetes[J]. J Dent Res. 2021,2021; 220345211009449.   (IF:6.116)

11.Zhang Y, Wang P, Wang Y, Li J,   Qiao D, Chen R, Yang W, Yan F*. Gold nanoparticles promote the bone   regeneration of periodontal ligament stem cell sheets through activation of   autophagy[J]. Int J Nanomedicine. 2021,16:61-73. (IF:5.115)

12.Cui D, Chen C, Luo B, Yan F*.   Inhibiting PHD2 in human periodontal ligament cells via lentiviral   vector-mediated RNA interference facilitates cell osteogenic differentiation   and periodontal repair[J]. J Leukoc Biol. 2021,1-11. (IF:4.962)

13.Li P, Zhang Y, Yan F*,   Zhou X*. Characteristics of a bacteriophage, vB_Kox_ZX8, isolated from   clinical klebsiella oxytoca and its therapeutic effect on mice bacteremia[J].   Front. Microbiol. 2021,12:763136. (IF:5.64)

14.Chen R, Qiao D, Wang P, Li L,   Zhang Y*, Yan F*. Gold nanoclusters exert bactericidal activity and   enhance phagocytosis of macrophage mediated killing of Fusobacterium   nucleatum[J]. Front. Mater. 2021,8:803871. (IF:3.515)

15.Wang X, Ye P, Fang L, Ge S, Huang   F, Polverini PJ, Heng W, Zheng L, Hu Q*, Yan F*, Wang W*. Active   smoking induces aberrations in digestive tract microbiota of rats[J]. Front.   Cell. Infect. Microbiol. 2021,11:737204. (IF:5.293)

16.Li Y, Du Z, Xie X, Zhang Y, Liu   H, Zhou Z, Zhao J, Lee RS, Xiao Y, Ivanoviski S, Yan F*. Epigenetic   changes caused by diabetes and their potential role in the development of   periodontitis[J]. J Diabetes Investig. 2021,12(8):1326-1335. (IF:3.761)

17.Zhang Y, Qiao D, Chen R, Zhu F,   Gong J, Yan F*. The association between periodontitis and inflammatory   bowel disease: a systematic review and Meta-analysis[J]. Biomed Res Int.   2021:6692420. (IF:3.411)

18.Li L, Zhang Y, Wang M, Zhou J,   Zhang Q, Yang W*, Li Y*, Yan F*. gold nanoparticles combined human   β-defensin 3 gene-modified human periodontal ligament cells alleviate   periodontal destruction via the p38 MAPK pathway[J]. Front Bioeng Biotechnol.   2021,9:631191. (IF:3.644)

19.Qian X, Zhang S, Duan L, Yang F,   Zhang K, Yan F*, Ge S*. Periodontitis deteriorates cognitive function   and impairs neurons and glia in a mouse model of Alzheimer's disease[J]. J   Alzheimers Dis. 2021,79(4):1785-1800. (IF:4.472)

20.Huang Y, Liao Y, Luo B, Li L,   Zhang Y, Yan F*. Non-surgical periodontal treatment restored the gut   microbiota and intestinal barrier in Apolipoprotein E-/- mice with   periodontitis[J]. Front Cell Infect Microbiol. 2020,10:498. (IF:4.123)

21.Li L, Jiang H, Chen R, Zhou J,   Xiao Y, Zhang Y*, Yan F*. Human β-defensin 3 gene modification   promotes the osteogenic differentiation of human periodontal ligament cells   and bone repair in periodontitis[J]. Int J Oral Sci. 2020,12(1):13.   (IF:3.047)

22.Zhang S, Yang F, Wang Z, Qian X,   Ji Y, Gong L, Ge S*, Yan F*. Poor oral health conditions and cognitive   decline: Studies in humans and rats[J]. PLoS One. 2020,15(7): e0234659.   (IF:2.74)

23.Ni C, Zhou J, Kong N, Bian T,   Zhang Y, Huang X, Xiao Y*, Yang W*, Yan F*. Gold nanoparticles   modulate the crosstalk between macrophages and periodontal ligament cells for   periodontitis treatment[J]. Biomaterials. 2019,206:115-132. (IF:10.273)

24.Zhang Q, Chen L, Chen B, Chen C,   Chang J, Xiao Y, Wu C, Yan F*. Lithium-calcium-silicate bioceramics   stimulating cementogenic/osteogenic differentiation of periodontal ligament   cells and periodontal regeneration[J]. Appl Mater Today. 2019,16:375-387.   (IF:8.013)

25.Liu J, Chen B, Bao J, Zhang Y,   Lei L*, Yan F*. Macrophage polarization in periodontal ligament stem   cells enhanced periodontal regeneration[J]. Stem Cell Res Ther.   2019,10(1):320. (IF:4.627)

26.Zhou J, Zhang Y, Li L, Fu H, Yang   W, Yan F*. Human β-defensin 3-combined gold nanoparticles for   enhancement of osteogenic differentiation of human periodontal ligament cells   in inflammatory microenvironments[J]. Int J Nanomedicine. 2018,13:555-567.   (IF:4.471)

27.Chen B, Ni Y, Liu J, Zhang Y, Yan   F*. Bone marrow-derived mesenchymal stem cells exert diverse effects on   different macrophage subsets[J]. Stem Cells Int. 2018,2018:8348121.   (IF:3.902)

28.錢俊,張楊珩,程書瑜,王南南,鄭麗純,李麗麗,闫福華.牙周炎患者唾液菌群對小鼠色氨酸-芳香烴受體信号軸的影響[J].中華口腔醫學雜志,2022,57(6):40-48.

29.王敏,張楊珩,闫福華.牙周炎與代謝綜合征關系的研究進展[J].中華口腔醫學雜志,2021,56(11):1138-1143.

30.譚葆春,闫福華. 控制菌斑和炎症在牙龈肥大治療中的效果評價[J].中華口腔醫學雜志,2021,56(6):510-516.

31.李麗麗,保珺,陳斌,闫福華. 高脂飲食加重牙周炎對腸道菌群及糖代謝影響的實驗研究[J].中華口腔醫學雜志,2021,56(6):539-548.

32.陳斌,李麗麗,張倩,劉娟,程群,闫福華. 侵襲性牙周炎、慢性牙周炎與牙周健康者龈下菌群的差異研究[J].中華口腔醫學雜志,2020,55(07):466-474.



1.國家自然科學基金項目面上項目,牙周炎介導的腸道菌群紊亂通過色氨酸-AhR信号軸調控雌激素缺乏狀态下牙槽骨吸收的機制研究,82270979,2023/01-2026/12,主持,在研。

2.江蘇省重點研發計劃社會發展面上項目,利用腸道菌群調控色氨酸-AhR信号軸治療高脂肥胖狀态下牙槽骨吸收的研究,BE20226702022/07-2025/06,主持,在研。

3.國家自然科學基金項目,牙周緻病菌腸道異位定植對高脂血症狀态下骨免疫微環境和骨重建的影響及其機制研究,819709392020/01-2023/12,主持,在研。


1. 2021年指導的張爽博士《手性金納米顆粒調節自噬促進骨再生的研究》被評為“2021年度南京大學優秀博士學位論文”;

2. 2020年《牙周炎對口腔和全身健康的危害及其關鍵防治技術的研究和推廣》項目獲得“教育部高等學校科學研究優秀成果獎(科學技術進步獎)二等獎”(1/15;

3. 2020年《微創牙周診療技術在重度牙周炎患牙保存中的應用》項目獲得“江蘇省新技術引進獎一等獎”(1/3);

4. 2010年《組織工程技術用于治療牙周疾病的實驗與臨床研究》項目獲得“福建省科學技術進步獎二等獎”(1/5);

5.2009年《立足海西建設需要培養口腔醫學人才》成果獲“福建省教學成果獎”二等獎)(2/6)。


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